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. Author manuscript; available in PMC: 2011 Aug 15.
Published in final edited form as: Arch Biochem Biophys. 2010 May 26;500(2):162–168. doi: 10.1016/j.abb.2010.05.022

Figure 5. Inhibition of endothelial barrier permeability by cell-penetrant iron chelating agents.

Figure 5

Cells cultured on filters for 6 d were incubated at 37 °C in culture medium that contained the indicated concentrations of desferrioxamine (circles) or dipyridyl (squares) above the cells and filters. After 120 min for desferrioxamine and 60 min for dipyridyl, 60 min transfer assays of 10 μM [carboxy-14C]inulin (Panel A) or 300 μM ascorbate (Panel C) were carried out. Intracellular ascorbate was also measured in the ascorbate transfer assay (Panel B). Results are shown from at least 3 experiments for each agent, with an “*” indicating p < 0.05 compared to untreated control.