Table 2.

Age and multivariable-adjusted hazard ratios for incident colorectal cancer among subjects diagnosed with diabetes at or prior to the baseline questionnaire, at or prior to the first follow-up questionnaire (1993–1995), or at or prior to the second follow-up questionnaire (1995–1997)

	Subjects with diagnosis of diabetesa	Cases among diabetics (Total cases in cohort = 489)	Age-adjusted HR (95% CI)	Multivariable-adjusted HR (95% CI)b
Prevalent diabetes at baseline (1987–1989)	2,438	42	1.56 (1.14–2.14)	1.49 (1.08–2.06)
Prevalent diabetes at 1993–1995 follow-up	3,328	50	1.37 (1.02–1.83)	1.36 (1.01–1.82)
Prevalent diabetes at 1995–1997 follow-up	3,978	58	1.35 (1.03–1.78)	1.35 (1.02–1.78)
Incident diabetes at 1993–1995 follow-upc	883	4	1.15 (0.43–3.10)	1.13 (0.42–3.08)

^aTotal number of subjects in the analytic cohort was 45,516. Total subjects at risk for colorectal cancer who returned a 1993–1995 questionnaire was 36,844

^bMultivariate models, in addition to age, adjust for physical activity, energy intake, alcohol, menopausal hormone therapy, smoking, multi-vitamin use, education, ethnicity, regular use of NSAIDs, intake of calcium from supplements, and energy adjusted intake of calcium from diet

^cIncident diabetes defined as new cases of diabetes reported on the 1993–1995 follow-up questionnaire among those returning a 1993–1995 questionnaire. Follow-up for this analysis began at the date of completion for the 1993–1995 questionnaire. The analysis excluded those who did not return a 1993–1995 questionnaire as well as people who were diagnosed with colorectal cancer prior to completion of the 1993–1995 questionnaire. Total number of cases among those at risk of colorectal cancer at 1993–1995 questionnaire and without prevalent diabetes at 1987–1989 questionnaire was 141. Methods, results, and discussion need to be modified