Table 3.
Age- and multivariable-adjusted hazard ratios for incident colorectal cancer among subjects diagnosed with diabetes modeling diabetes as a time-dependent variable and considering different durations of time at study exit with a diabetes diagnosis compared to subjects without a diagnosis of diabetes at study exit
| Colorectal cancer cases (person years)a |
Age-adjusted HR (95% CI) |
Multivariable-adjusted HR (95% CI)b |
|
|---|---|---|---|
| Diabetes modeled as a time-dependent variable | 489 | 1.64 (1.21–2.22) | 1.60 (1.18–2.18) |
| Time with diabetes diagnosis | |||
| 0 years | 443 (360,851) | 1.00 (ref) | 1.00 (ref) |
| 0–4 years | 6 (6,009) | 1.02 (0.34–3.02) | 0.97 (0.33–2.89) |
| 4–8 years | 14 (5,156) | 2.55 (1.04–6.25) | 2.36 (0.96–5.79) |
| 8–12 years | 9 (3,844) | 1.86 (0.69–5.01) | 1.71 (0.63–4.61) |
| ≥12 years | 17 (7,512) | 1.08 (0.51–2.29) | 1.01 (0.48–2.13) |
Total number of subjects in the analytic cohort was 45,516. Person years for model of diabetes as a time-dependent variable is the total person years in the cohort. Person years for model of time with diagnosis of diabetes is person years in each category
Multivariate models, in addition to age, adjust for physical activity, energy intake, alcohol, menopausal hormone therapy, smoking, multi-vitamin use, education, ethnicity, regular use of NSAIDs, intake of calcium from supplements, and energy adjusted intake of calcium from diet