Table 3.

Odds Ratios, Confidence Intervals, and P-values for Single Nucleotide Polymorphisms in Age-Related Macular Degeneration-Associated Genes (CFH, LOC387715, C2, C3, APOE, and TLR3) in Age-Related Eye Disease Study Participants with Geographic Atrophy (N=114) and Age-Related Eye Disease Study Controls with no Age-Related Macular Degeneration^a (N=448)

Gene SNP	type	Nb	Genotypic OR (CI)c	Genotypic P-value	Allelic OR (CI)d	Allelic P-Value
CFH rs1061170	GA	107	7.36 (3.87 –13.97)	<0.0001	2.77 (2.042–3.77)	<0.0001
	No AMD	437
LOC387715 rs10490924	GA	106	6.01 (3.48–10.38)	<0.0001	3.67 (2.67–5.05)	<0.0001
	No AMD	436
C2 rs2230199	GA	113	-	-	0.23 (0.07–0.75)	0.0134
	No AMD	447
C3 rs9332739	GA	114	6.22 (2.79–13.85)	<0.0001	2.5 (1.81–3.45)	<0.0001
	No AMD	448
APOE rs7412	GA	112	-	-	1.37 (0.84–2.22)	0.256
	No AMD	447
APOE rs429358	GA	113	-	-	0.61 (0.37–0.99)	0.062
	No AMD	443
TLR3 rs3775291	GA	114	1.55 (0.77–1.67)	0.149	1.22 (0.896–1.67)	0.233
	No AMD	448

^aLess than 5 small drusen (<63 micron diameter) in both eyes

^bNumber of participants genotyped

^cRisk homozygote vs. non-risk homozygote. For C2 and APOE, there was an insufficient frequency of the minor-allele homozygotes for calculation of genotypic odds ratios.

^dallelic odds ratio (confidence interval)