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. Author manuscript; available in PMC: 2010 Jul 15.
Published in final edited form as: Annu Rev Immunol. 2007;25:561–586. doi: 10.1146/annurev.immunol.25.022106.141656

Figure 5.

Figure 5

Structural features of CARDs and CARD: CARD interactions. (a) A stereo diagram of superimposed known CARD structures. Red: Apaf-1 CARD, Blue: ICEBERG CARD, Green: RAIDD CARD; Cyan: caspase-9 CARD; Violet: CED4 CARD. (b) Superimposed Apaf-1 CARD structures when determined alone (green), in complex with caspase-9 (violet) and in WD-deleted Apaf-1 (red). (c) Surface features of CARDs, showing the charged surfaces. Two orientations are shown, one similar to the caspase-9 interaction surface of Apaf-1 (left) and the other similar to the Apaf-1 interaction surface of caspase-9 (right). (d) Apaf-1 CARD: caspase-9 CARD structure. Apaf-1 CARD is shown in violet and caspase-9 CARD is in cyan.