Table 1.
Responses in plasma and urine parameters to low or high NaCl intake
Control |
STZ diabetes |
|||||||
---|---|---|---|---|---|---|---|---|
WT |
A1R−/− |
WT |
A1R−/− |
|||||
low NaCl | high NaCl | low NaCl | high NaCl | low NaCl | high NaCl | low NaCl | high NaCl | |
[Na+]pl, mmol/l | 158 ± 2 | 156 ± 2 | 154 ± 1 | 154 ± 1 | 155 ± 2 | 151 ± 2 | 150 ± 1 | 153 ± 2 |
[K+]pl, mmol/l | 5.1 ± 0.2 | 5.0 ± 0.2 | 5.0 ± 0.2 | 5.2 ± 0.2 | 4.2 ± 0.2 | 4.4 ± 0.1 | 4.3 ± 0.1 | 4.7 ± 0.1 |
[Gluc]bl, mg/dl | 156 ± 22 | 155 ± 21 | 152 ± 17 | 147 ± 17 | 461 ± 25 | 449 ± 9 | 461 ± 12 | 475 ± 11 |
Hct, % | 48 ± 2 | 48 ± 1 | 48 ± 2 | 48 ± 2 | 53 ± 3 | 53 ± 2 | 53 ± 2 | 52 ± 1 |
[Gluc]/[Crea]u, mg/mg | 2.3 ± 0.2 | 2.2 ± 0.2 | 2.2 ± 0.1 | 1.6 ± 0.3 | 190 ± 48 | 147 ± 27 | 206 ± 75 | 149 ± 69 |
[Alb]/[Crea]u, (μg/mg | 0.21 ± 0.01 | 0.21 ± 0.04 | 0.30 ± 0.06 | 0.24 ± 0.09 | 1.36 ± 0.30 | 1.68 ± 0.37 | 0.91 ± 0.21 | 0.64 ± 0.11 |
Data are means ± SE; n = 5–6 per group. [Na+]pl, [K+]pl = plasma concentration of Na+ and K+, respectively; [Gluc]bl = blood glucose concentration; Hct = hematocrit; Crea = creatinine; u = urine; Alb = albumin.