Expression of four conserved vascular related genes in primary and metastatic brain tumors. Immunohistochemical staining for COL4A1, MMP14 and SOX4 on representative tissue microarray specimens. Localization by in situ hybridization for PXDN on representative tissue microarray specimens. PA pilocytic astrocytoma, Met metastatic brain tumor, GBM glioblastoma. Original magnification of far right column, ×400; all other images, ×200