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Schematic representation of the reciprocal interaction between serotonin (5‐HT) neurons in the dorsal raphe nucleus, norepinephrine (NE) neurons in the locus coeruleus and dopamine (DA) neurons in the ventral tegmental area. It also shows the nature of modulation of different neurotransmitters on diverse classes of auto‐ and heteroreceptors. (+) signs indicate an agonism or stimulatory effect and (–) signs indicate an antagonism or an inhibitory effect.
