Figure 3.

Effect of single‐ and dual‐acting catecholaminergic reuptake inhibitors on escitalopram‐induced decrease in DRN 5‐HT neuronal activity. (A, B): Examples of integrated firing histograms showing the effects of cumulative intravenous doses of escitalopram on the spontaneous activity of DRN 5‐HT neurons in presence of vehicle (A), or of the DA/NE reuptake inhibitor nomifensine (5 mg/kg; iv; B). The arrows indicate the compounds administered and the time at which the injection of the specified doses was completed. The escitalopram‐induced inhibition of firing rate was reversed with the 5‐HT_1A receptor antagonist WAY100635. (C) Symbols represent the mean (± SEM) of percent of baseline firing rate of DRN 5‐HT neurons observed at each dose of escitalopram after the administration of vehicle; GBR 12909, reboxetine and nomifensine. These means were calculated on the 60 second‐period preceding each drug administration. ***P < 0.001. Statistical significance was taken as P < 0.05.