Figure 6.

Diagrams of NE neurons representing their response and adaptations to the inhibition of the NE and DA transporters with nomifensine or release of DA and NE by bupropion. The spikes on the axons represent the firing activity of NE neurons. The dots around NE neuron represent NE molecules. These neurons have α₂ autoreceptors that inhibit firing and release when activated by an excess amount of NE. The effects of NE on postsynaptic neurons are mediated by several subtypes of α‐ and β ‐adrenergic receptors. NRI, norepinephrine reuptake inhibitor.