Table 1.
Effect of long‐term administration of various antidepressant medications with affinities for NE and DA elements on DA, NE and 5‐HT neurotransmissions
| Cell body α2 autoreceptor | Cell body D2 autoreceptor | Cell body 5‐HT1A autoreceptor | Net NE transmission | Net DA transmission | Net 5‐HT transmission | |
|---|---|---|---|---|---|---|
| Pramipexole | ↓ | ↓ | ↓ | N.D. | ↑ | ↑ |
| NRI | Ø | N.D. | Ø | ↑ | ↑* | ↑ |
| Nomifensine | Ø | ↓ | ↓ | ↑* | ↑* | ↑* |
| Bupropion | ↓ | N.D. | ↓ | ↑ | ↑* | ↑ |
| Mirtazapine | Ø# | N.D. | ↓ | ↑ | ↑ | ↑ |
| SSRI | N.D. | N.D. | ↓ | ↓ | ↓ | ↑ |
N.D., not determined; ø, no change; ↑, increased; ↓, decreased; *, presumed from their acute effect; #, these experiments were carried out after a washout, but in the presence of mirtazapine this receptor is antagonized.