Skip to main content
. Author manuscript; available in PMC: 2010 Jul 15.
Published in final edited form as: Endocrinology. 2006 Aug 31;147(12):5653–5661. doi: 10.1210/en.2006-1055

Fig. 7.

Fig. 7

PAPP-A transgenic mice show increased calvarial bone thickness and skull BMD. The thickness of the isolated calvarial bones was determined by a digital caliper. Skull BMD was measured by DEXA on anesthetized animals (Materials and Methods). Eight-month-old F1 females [three wild-type (Wt.) and three transgenic (Tg.) mice] and 3-month-old F2 males (five wild-type and five transgenic mice) were derived from founder 26. The in vivo skull BMD of the founder 2 mouse (male) measured at an age of 8 months was compared with the average BMD of three wild-type male mice with similar age and genetic background. The in vivo skull BMD of the female F1 progeny of line 12 (one of the three new lines subsequently developed) was analyzed at the age of 5 months of age (n = 3). *, P < 0.05; **, P < 0.01 compared with values of wild-type mice.