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. Author manuscript; available in PMC: 2011 Jul 8.
Published in final edited form as: J Med Chem. 2010 Jul 8;53(13):4906–4916. doi: 10.1021/jm1002952

Table 3.

Data against HIV-1IIIB and A17 in the MT-2 cell line*

Compound EC50 (μM) in MT-2 cell line
 RF
IIIB (wild-type) A17 (Y181C/K103N) a
34 0.211 ± 0.053 15.469 ± 9.035 73.3
36 0.052 ± 0.005 1.055 ± 0.088 20.3
37 0.032 ± 0.005 0.604 ± 0.179 18.9
4 0.058 ± 0.001 0.575 ± 0.093 9.9
*

Data provided by Dr. Shibo Jiang, New York Blood Center, US. Results are average of three independent assays.

a

The multi-NRTI-resistant strain A17 from NIH with mutations at amino acids 103 (K → N) and 181 (Y → C) in the viral RT domain is highly resistant to NRTIs21.