Table 3.

Risk of progression to multiple myeloma and related disorders among Olmsted County, Minnesota residents with light chain-monoclonal gammopathy of undetermined significance (LC-MGUS), conventional MGUS, and no MGUS

	Number of progressors/Person-years [Progression rate per 100-years (95%CI)]
	Abnormal FLC with elevated light chain	FLC ratio abnormal but no high component	FLC ratio normal	Total
No conventional MGUS	3/1,110^* [0.27 (0.06, 0.79)^*]	1/2,290 [0.04 (0, 0.24)]	13/147,620 [0.01 (0.01, 0.02)]	17/151,020 [0.01 (0.01, 0.02)]
MGUS (detected in original study) ²	20/850^† [2.36 (1.44, 3.65)^†]	4/250^† [1.59 (0.43, 4.07) ^†]	17/3,080^‡ [0.55 (0.32, 0.89)^‡]	41/4,170 [0.98 (0.71, 1.33)]
MGUS (newly detected in current study)	3/240^† [1.27 (0.26, 3.7) ^†]	1/120^† [0.87 (0.02, 4.84)^†]	NA^‡ [NA^‡]	4/350 [1.14 (0.31, 2.91)]
Total	26/2,190 [1.19 (0.77, 1.74)]	6/2,660 [0.23 (0.08, 0.49)]	30/150,690 [0.02 (0.01, 0.03)]	62/155,540 [0.04 (0.03, 0.05)]

Light chain MGUS population

^†

Conventional MGUS, increased risk as defined as abnormal FLC-R

^‡

Conventional MGUS, low risk as defined as normal FLC-R

NA, not applicable