Table 2.
Rat Homologues of Developmental Genes That Vary Among Depots in Human Preadipocytes
| Gene Symbol | Perirenal/Epididymal Fold Difference | Adjusted p Value (Perirenal vs Epididymal) |
| Krt1-18 (Krt-18) | 3.39 | 0.0332 |
| Hoxa4 | 2.49 | 0.0056 |
| Hoxa5 | 2.53 | 0.0060 |
| Hoxa2 | 1.03 | 0.7610 |
| Pitx2 | 4.17 | 0.0212 |
| Twist1 | 7.72 | 0.0106 |
| Prrx1 (Pmx-1) | 9.78 | 0.0003 |
| Prrx2 (Prx-2) | 1.48 | 0.0003 |
| Kitl (Kitlg) | 2.80 | 0.0007 |
| Hoxa10 | 9.36 | 0.0012 |
Notes: We previously confirmed inherent variation of 20 developmental genes among human preadipocytes isolated from different fat depots [figure 4 in (17)]. Of these, 11 have homologs on Affymetrix rat 230 array sets, 10 of which met the same scaling criteria for expression in rat preadipocytes as in our human studies. Of the 10 genes present, 9 exhibited differences in expression between perirenal and epididymal preadipocytes (false discovery rate < 0.05), despite species differences and differences in depots being compared in the human and rat studies.