Table 2.
Fold change in the expression of genes that are essential for placental development in placentas of IUGR fetuses.*
| Placental function | Gene | Gene product | Fold Change** |
|---|---|---|---|
| Spongiotrophoblast maintenance |
Ascl2 (Mash2) |
bHLH transcription factor | −1.96 |
| Regulation of fetal-placental growth | Igf2 | Insulin-like growth factor 2 | −1.92 |
| Chorioallantoic branching and labyrinthine development |
Gcm1 | Transcription factor | −1.85 |
| Vascularization of labyrinth | Esx1 | Homeobox transcription factor | −1.69 |
| Chorioallantoic branching and labyrinthine development |
Pparg | Nuclear hormone receptor | −1.67 |
| Chorioallantoic branching and labyrinthine development |
Dlx3 | Homeobox transcription factor | −1.59 |
| Trophoblast giant cell differentiation | Hand1 | bHLH transcription factor | −1.51 |
| Chorioallantoic branching and labyrinthine development |
Pdgfra | Platelet-derived growth factor receptor α |
−1.48 |
| Nutrient transport across labyrinth |
Gjb2 (Cx26) |
Connexin, gap junction protein | −1.41 |
| Trophoblast lineage development | Fgf4 | Fibroblast growth factor 4 | −1.31 |
| Ectoplacental cone function | Ets2 | Ets domain transcription factor | −1.29 |
| Chorioallantoic branching and labyrinthine development |
Fzd5 | Frizzled 5, Wnt receptor | −1.25 |
*
Genes determined with knockout mouse modelsError! Bookmark not defined.
**
Raw microarray data