Table 1.
ID# | Relationship to Proband |
Age (years) |
Weight (kg) |
BMI (kg/m2) |
IPF1 Mutation |
Oral Glucose Tolerance Test (hour) | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Fasting | ½ | 1 | 1½ | 2 | HbA1c | |||||||
IV-23 | Father | 23 | 116 | 39 | Yes | Glucose (mg/dl) | 155 | 283 | 305 | 282 | 265 | 6.1 |
Insulin (µU/mL) | 98 | 229 | 246 | 261 | 284 | |||||||
C-peptide (ng/mL) | 8.0 | 14.6 | 17.6 | 19.2 | 21.4 | |||||||
IV-24 | Mother | 21 | 110 | 41.8 | Yes | Glucose (mg/dl) | 147 | 241 | 219 | 152 | 160 | 5.7 |
Insulin (µU/mL) | 39 | 164 | 135 | 66 | 100 | |||||||
C-peptide (ng/mL) | 5.0 | 14.9 | 15.8 | 13.4 | 13.7 | |||||||
V-2 | Sister* | 2.5 | 14 | 17.7 | Yes | Glucose (mg/dl) | 104 | 204 | 141 | 135 | 116 | 5.4 |
Insulin (µU/mL) | 6 | 63 | 26 | 34 | 19 | |||||||
C-peptide (ng/mL) | 0.7 | 6.3 | 6.1 | 5.6 | 3.9 | |||||||
IV-25 | Maternal uncle |
20 | 103 | 31.8 | No | Glucose (mg/dl) | 99 | 195 | 207 | 210 | 215 | 5.4 |
Insulin (µU/mL) | 34 | 167 | 135 | 186 | 277 | |||||||
C-peptide (ng/mL) | 3.0 | 11.1 | 12.5 | 15.4 | 17.7 | |||||||
IV-22 | Paternal uncle | 19 | 90 | 31.4 | No | Glucose (mg/dl) | 108 | 159 | 160 | 112 | 111 | 5.7 |
Insulin (µU/mL) | 34 | 280 | 284 | 248 | 151 | |||||||
C-peptide (ng/mL) | 2.4 | 14.6 | 18.3 | 15.5 | 13.6 |
In last 9 months, many 2-hr post-dinner blood glucose levels ranged between 200–270 mg/dL while others were 96–100 mg/dL.
Note that HbA1c concentrations for IV-23, IV-24, and IV-25 are not diagnostic for diabetes (≤ 6.5%) while FPG or OGTT values are.