Table 1.

Oral Glucose Tolerance Tests in Members of the Michigan-Kentucky Pedigree with and without the IPF1 Mutation Pro63fsX60 (1.75 gm glucose per kg ideal body weight)

ID#	Relationship to Proband	Age (years)	Weight (kg)	BMI (kg/m2)	IPF1 Mutation		Oral Glucose Tolerance Test (hour)
							Fasting	½	1	1½	2	HbA1c
IV-23	Father	23	116	39	Yes	Glucose (mg/dl)	155	283	305	282	265	6.1
						Insulin (µU/mL)	98	229	246	261	284
						C-peptide (ng/mL)	8.0	14.6	17.6	19.2	21.4
IV-24	Mother	21	110	41.8	Yes	Glucose (mg/dl)	147	241	219	152	160	5.7
						Insulin (µU/mL)	39	164	135	66	100
						C-peptide (ng/mL)	5.0	14.9	15.8	13.4	13.7
V-2	Sister*	2.5	14	17.7	Yes	Glucose (mg/dl)	104	204	141	135	116	5.4
						Insulin (µU/mL)	6	63	26	34	19
						C-peptide (ng/mL)	0.7	6.3	6.1	5.6	3.9
IV-25	Maternal uncle	20	103	31.8	No	Glucose (mg/dl)	99	195	207	210	215	5.4
						Insulin (µU/mL)	34	167	135	186	277
						C-peptide (ng/mL)	3.0	11.1	12.5	15.4	17.7
IV-22	Paternal uncle	19	90	31.4	No	Glucose (mg/dl)	108	159	160	112	111	5.7
						Insulin (µU/mL)	34	280	284	248	151
						C-peptide (ng/mL)	2.4	14.6	18.3	15.5	13.6

^*In last 9 months, many 2-hr post-dinner blood glucose levels ranged between 200–270 mg/dL while others were 96–100 mg/dL.

Note that HbA1c concentrations for IV-23, IV-24, and IV-25 are not diagnostic for diabetes (≤ 6.5%) while FPG or OGTT values are.