Table 1.

Candidate molecules of the p53 pathway obtained by p53 RT²-PCR pathway array

Gene symbol	GenBank ID	Gene description	Mean fold changes
Upregulated genes
Apex1	NM_009687	Apurinic/apyrimidinic endonuclease 1	2.86
Bag1	NM_009736	Bcl2-associated athanogene 1	2.14
ccng1	NM_009831	Cyclin G1	2.53
Cradd	NM_009950	CASP2 and RIPK1 domain containing adaptor with death domain	2.10
Gadd45a	NM_007836	Growth arrest and DNA-damage-inducible 45 alpha	3.36
Msh2	NM_008628	MutS homolog 2 (Escherichia coli)	2.29
Pttg1	NM_013917	Pituitary tumour-transforming 1	17.85
Rprm	NM_023396	Reprimo, TP53-dependent G2 arrest mediator candidate	2.92
Sfn	NM_018754	Stratifin	5.97
Xrcc5	NM_009533	X-ray repair complementing defective repair in Chinese hamster cells 5	2.03
Downregulated genes
Apaf1	NM_009684	Apoptotic peptidase activating factor 1	2.13
Bcl2	NM_009741	B-cell leukaemia/lymphoma 2	3.25
Bid	NM_007544	BH3 interacting domain death agonist	2.45
Brca1	NM_009764	Breast cancer 1	2.16
Cdc2a	NM_007659	Cell division cycle 2 homolog A (Schizosaccharomyces pombe)	2.55
Cdkn1a	NM_007669	Cyclin-dependent kinase inhibitor 1A (P21)	2.85
E2f1	NM_007891	E2F transcription factor 1	2.00
FasL	NM_010177	Fas ligand (TNF superfamily, member 6)	2.61
IL6	NM_031168	Interleukin 6	13.66
Myc	NM_010849	Myelocytomatosis oncogene	4.73
Pmaip1	NM_021451	Phorbol-12-myristate-13-acetate-induced protein 1	2.66
Traf1	NM_009421	Tnf receptor-associated factor 1	2.91
Vcan	XM_488510	Versican	3.19
wt1	NM_144783	Wilms tumour homolog	2.03

Selected up- and downregulated transcripts of the p53 pathway in p53^−/−/myo^+/+ mice (fold changes over myo-Tg mice) based on a cut-off value of 2. Values are expressed as the mean of fold changes from three independent experiments.