. Author manuscript; available in PMC: 2010 Jul 15.

Published in final edited form as: J Cardiovasc Pharmacol. 2009 Jul;54(1):47–56. doi: 10.1097/FJC.0b013e3181ab371d

TABLE 1.

Hemodynamic, Echocardiographic, and Other Parameters for DS Rats in the 5 Experimental Groups at 19 Weeks of Age

Parameter	Control	HF	HYD	OLM + AZE	APO
Body weight (g)	417 ± 16	376 ± 24	406 ± 17	412 ± 19	401 ± 21
Heart rate (bpm)	416 ± 12	478 ± 23	501 ± 16	426 ± 18	450 ± 16
SBP (mm Hg)	151 ± 4	229 ± 3^*	205 ± 208^†	208 ± 5^†	217 ± 6
LVW:BW (mg/g)	2.2 ± 0.1	3.5 ± 0.3^*	2.7 ± 0.2^†	2.4 ± 0.2^‡	2.8 ± 0.3^†
Lung weight (wet/dry)	4.2 ± 0.3	6.7 ± 0.5^*	5.2 ± 0.4^†	4.3 ± 0.3^‡	4.9 ± 0.4^†
IVST (mm)	1.4 ± 0.1	2.1 ± 0.1^*	1.7 ± 0.1^†	1.6 ± 0.1^†	1.8 ± 0.1^†
LVDd (mm)	7.1 ± 0.1	9.4 ± 0.4^*	8.1 ± 0.2^†	7.4 ± 0.2^†	8.2 ± 0.3^†
LVFS (%)	46 ± 1	34 ± 2^*	43 ± 1^†	48 ± 2^†	41 ± 1^†
dp/dt_max (mm Hg/s)	9284 ± 1124	7127 ± 927^*	9467 ± 2034^†	11,990 ± 1113^‡	10,132 ± 2314^†
dp/dt_min (mm Hg/s)	12,167 ± 1466	7796 ± 1019^*	9039 ± 2405^*	13,167 ± 917^‡	10,800 ± 2014^*^†
T_1/2 (ms)	3.4 ± 0.1	5.5 ± 0.2^*	4.9 ± 0.3^*	3.7 ± 0.2^‡	4.4 ± 0.2^*^†
LVEDP (mm Hg)	4.8 ± 0.5	16.5 ± 1.5^*	14.5 ± 1.4^*	6.9 ± 0.5^‡	9.3 ± 1.5^*^†
Elastolytic activity	450 ± 56	1980 ± 134^*	1810 ± 201^*	750 ± 88^†	1259 ± 109^†
Ang II (pg/mg LVW)	155 ± 13	360 ± 43^*	346 ± 51^*	178 ± 45^†	308 ± 65^*

Elastolytic activity is expressed in fluorescence units. Data are means ± SEM for at least 6 animals of each group.

P < 0.05 versus control group;

^†

P < 0.05,

^‡

P < 0.01 versus HF group.

Ang II, angiotensin II; BW, body weight; IVST, interventricular septum; LVEDP, left ventricular end-diastolic pressure; LVFS, left ventricular fractional shortening; LVW, left ventricular weight; SBP, systolic blood pressure.