Figure 3. DCB-3503 inhibited incorporation of amino acid in a time- and dose-dependent manner.

A. DCB-3503 inhibited [³H]-amino acid incorporation in both time- (a) and dose-dependent (b) manner in HepG2 cells. B. DCB-3503 inhibited [³H]-amino acid incorporation in HeLa cells (a) and PANC-1 cells (b) in a dose-dependent fashion. A and B results from three separate experiments are presented as mean ± S.D. C. Inhibitory effect of DCB-3503 on global protein synthesis and cyclin D1 protein synthesis assessed by [³⁵S]-methionine/cysteine incorporation. This is a representative from three separate experiments.