Figure 4. DCB-3503 preferentially inhibited [¹⁴C]-thymidine incorporation in a time- and dose-dependent manner, but not [¹⁴C]-uridine incorporation.

A. and B. The inhibitory effect of DCB-3503 on [¹⁴C]-thymidine incorporation was time-dependent and dose-dependent in HepG2 cells. (C) and (D) DCB-3503 showed less than 50% inhibition on [¹⁴C]-uridine incorporation in either HepG2 cells followed by different time and dose treatment. Hydroxyurea (Hu) and actinomycin D were used as positive controls. Values are depicted as mean ± S.D. from at least three separate experiments.