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Schematic diagram illustrating a model of interstitial fluid turnover in the brain based on secretion of cerebral ISF by the blood brain barrier (open arrows) and bulk flow of ISF from brain to CSF via perivascular spaces (curved arrows). CSF is secreted by the choroid plexus (open arrows) and drains with ISF from the subarachnoid space into venous blood and lymph (reproduced with permission from Cserr et al [51]).
