Table 8.
Partial relation of oral antidiabetic drugs at combination therapy: two substances in a single pill
| Therapeutic classes | Chemical Denomination | Commercial Denomination | Action and Dosage Mechanism |
|---|---|---|---|
| biguanide + sulphonylurea |
metformin + glibenclamide |
Glucovance® Merck |
Peripheral action insulin sensitizer (metformin) + long-acting secretagogue of insulin (glibenclamide). Dosage: 250 mg metformin+1.25 mg glibenclamide 500 mg metformin + 2.5 mg glibenclamide 500 mg metformin + 5 mg glibenclamide. |
| glitazone + biguanides |
rosiglitazone + metformin |
Avandamet® Glaxo |
Combination of two peripheral action insulin sensitizers, with different action Dosage: 2 mg rosiglitazone + 500 mg metformin 4 mg rosiglitazone + 500 mg metformin. |
| Incretin mimetic + metformin |
sitagliptin + metformin |
Janumet® MSD |
DPP-4inhibitor + peripheral action insulin sensitizer (metformin). Dosage: 50 mg sitagliptin + 500, 850 or 1,000 mg metformin |
| Incretin mimetic + metformin |
vildagliptin + metformin |
Galvus Met® Novartis |
DPP-4 inhibitor + peripheral action insulin sensitizer (metformin). Dosage: 50 mg vildagliptin + 500, 850 or 1,000 mg metformin |
This table presents only a partial list of commercial medications of various drugs and does not represent a specific recommendation of any commercial brand.