Table 2.

Prevalence of CNS medication use and dose information over time

CNS medication use	Year 1 (n=3055)%	Year 2 (n=2911)%	Year 3 (n=2693)%	Year 5 (n=2480)%
Any CNS use	13.88	14.50	16.30	18.02
Antidepressant use	6.22	6.73	8.47	9.31
Antipsychotic use	0.72	0.72	0.89	0.89
Benzodiazepine receptor agonist use	5.99	6.05	6.13	6.73
Opioid analgesic receptor agonist use	3.73	4.12	4.49	5.00
Use of 2+ agents	2.98	3.85	4.34	4.29
High dose use (>3 SDD)	2.39	2.85	3.04	3.43
Medium dose use (1–3 SDD)	3.50	4.19	5.76	6.33
Low dose use (<1.0 SDD)	7.99	7.46	7.50	8.27
Long term use (2+ years)	7.79	10.07	11.33	11.33
Short-term use (<2 years)	6.09	4.43	4.98	6.69

Abbreviations: CNS=central nervous system; SDD=standardized daily dose.