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. Author manuscript; available in PMC: 2011 Jul 7.
Published in final edited form as: J Am Chem Soc. 2010 Jul 7;132(26):8973–8983. doi: 10.1021/ja1007867

Figure 1. Zinc inhibits hIAPP amyloid fibril formation at pH 7.5.

Figure 1

Amyloid formation by hIAPP as a function of zinc concentration as followed by the amyloid-specific dye Thioflavin T. (A) 5μM and (B) 10 μM hIAPP with indicated concentrations of ZnCl2. Traces are averages for n=9 (5 μM hIAPP) and n =7 (10 μM hIAPP) runs. The kinetic analysis of these traces and the variation of the final THT fluorescence intensity as a function of zinc concentration (along with the associated error bars) are given in Figures 4 and 2 respectively.