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. Author manuscript; available in PMC: 2011 Jul 7.
Published in final edited form as: J Am Chem Soc. 2010 Jul 7;132(26):8973–8983. doi: 10.1021/ja1007867

Figure 10.

Figure 10

Top: Histogram of NOEs versus the amino acid residues for hIAPP (A) without ZnCl2 and (B) with ZnCl2, showing the number of intra-residue, sequential (i – j = 1), and medium range (i – j = 2, 3, 4) NOEs. Bottom: Summary of the sequential and medium range NOE connectivities for hIAPP (C) without ZnCl2 and (D) with ZnCl2, The intensities of the observed NOEs are represented by the thickness of lines and are classified as strong, medium, and weak, corresponding to upper bound constraints of 2.9, 4.5, and 6 Å, respectively.