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. Author manuscript; available in PMC: 2011 Jul 7.
Published in final edited form as: J Am Chem Soc. 2010 Jul 7;132(26):8973–8983. doi: 10.1021/ja1007867

Figure 2. Zinc decreases the equilibrium concentration of hIAPP fibers at pH 7.5.

Figure 2

Variation in the fluorescence intensity of the amyloid-bonding dye Thioflavin T as a function of ZnCl2 concentration after fibrillogenesis has completed as extracted from the experimental results presented in Figure 1. Values for 5 μM and 10 μM were determined after 2 and 1 day(s) respectively. The intensity values were normalized to hIAPP in the absence of zinc. Error bars indicate standard error of measurement (S.E.M) for n=9 (5 μM hIAPP) and n =7 (10 μM hIAPP). Inset shows the effect at lower ZnCl2 concentrations (0 - 1000 μM).