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. Author manuscript; available in PMC: 2011 Jul 7.
Published in final edited form as: J Am Chem Soc. 2010 Jul 7;132(26):8973–8983. doi: 10.1021/ja1007867

Figure 3. Zinc reduces the density of hIAPP fibrils while maintaining a similar fibril morphology.

Figure 3

Top: Electron micrographs showing the effect of zinc on total amyloid deposition and fiber morphology. Aliquots from a 100 μM hIAPP solution incubated with (A) 0 μM ZnCl2, (B) 100 μM ZnCl2 and (C) 1000 μM ZnCl2 were deposited on copper grids after an incubation period of 2 days and imaged at 6500x magnification. Bottom: Electron micrographs of hIAPP incubated with (D) 0 μM ZnCl2, (E) 100 μM ZnCl2 and (F) 1000 μM ZnCl2 imaged at 15000x magnification.