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. Author manuscript; available in PMC: 2011 Jul 7.
Published in final edited form as: J Am Chem Soc. 2010 Jul 7;132(26):8973–8983. doi: 10.1021/ja1007867

Figure 4. Zinc has a bimodal effect on hIAPP fibrillogenesis at pH 7.5.

Figure 4

Analysis of the kinetics of hIAPP at pH 7.5 according to a sigmoidal growth model. A variation in the lag-time (t1/2-2/k) before detectable fiber formation as a function of ZnCl2 at (A) 5 μM and (B) 10 μM hIAPP. Variations in the apparent first-order elongation rate constant (k) at (C) 5 μM and (D) 10 μM hIAPP. Error bars indicate standard error of measurement (S.E.M) for n=9 (5 μM hIAPP) and n =7 (10 μM hIAPP). Insets show the effect from 0–500 μM ZnCl2.