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. Author manuscript; available in PMC: 2011 Jul 7.
Published in final edited form as: J Am Chem Soc. 2010 Jul 7;132(26):8973–8983. doi: 10.1021/ja1007867

Figure 8. Zinc binding causes a local disruption of the secondary structure in the vicinity of His-18.

Figure 8

High-resolution NMR structures of hIAPP in the absence (A) and presence of 10 mM ZnCl2 (B).