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Alpha proton chemical shift indexes (CSI) for hIAPP (A) and hIAPP in the presence of 10 mM zinc (B). The CSI was calculated by subtracting the appropriate random coil shifts reported in the literature. A CSI ≤ 0.1 is considered indicative of helical conformations. Changes in Hα (C) and HN (D) chemical shifts upon binding to zinc.
