Table 1.
Statistical information for the hIAPP and hIAPP-Zn+2 structural ensembles
| IAPP | IAPP+Zn2+ | ||
|---|---|---|---|
| Distance constraints | Total | 435 | 460 |
| Intraresidual | 156 | 171 | |
| Interresidual | 279 | 289 | |
| Sequential (i-j = 1) | 135 | 153 | |
| Medium (i-j = 2–4) | 144 | 136 | |
| Structural statistics | Violated distance constraints | 0 | 4 |
| Violated angle constraints | 0 | 0 | |
| RMSD of all backbone atoms (Å) | |||
| Q10 – L27 | 0.47 ± 0.19 | ||
| Q10 – T30 | 0.33 ± 0.12 | ||
| RMSD of all heavy atoms (Å) | |||
| Q10 – L27 | 1.15 ± 0.34 | ||
| Q10 – T30 | 1.21 ± 0.26 | ||
| Ramachandran plot | Residues in most favored region (%) | 72.1 | 64.5 |
| Residues in additionally allowed region (%) | 22.4 | 29.4 | |
| Residues in generously allowed region (%) | 5.5 | 6.1 |