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. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: Neuropharmacology. 2009 Jul 14;57(5-6):556–566. doi: 10.1016/j.neuropharm.2009.07.013

Table 1.

Protein identification and differential hippocampal protein levels. UniProtKB accession numbers are provided and proteins in bold are reflecting the level of significance p < 0.05.

Accession number Protein name Spot no. WT KO MS score Matched peptides Sequence coverage % Theor. MW Theor. pI Obs. pI MS/MS-peptide sequences
O35864 COP9 signalosome complex subunit 5 0.19 ± 0.08 0.18 ± 010 138 17 47 37,417.59 6.11 6.0 K.GYKPPDEGPSEYQTIPLNK.I
O55131 Similar to Septin-7, O55131, (93%) 0.22 ± 0.10 0.15 ± 0.08 67 8 31 50,549.86 8.73 8.8
O88441 Metaxin-2 (Involved in transport of proteins into the mitochondrion.) 0.28 ± 0.10 0.31 ± 0.06 98 9 55 29,758.12 5.44 5.5
O88544 COP9 signalosome complex subunit 4 0.12 ± 0.09 0.11 ± 0.06 380 21 63 46,284.81 5.57 5.65 R.VISFEEQVASIR.Q
K.HALHCTILASAGQQR.S
R.LYLEDDDPVQAEAYINR.A
P12658 Calbindin 1.10 ± 0.24 1.25 ± 0.21 64 5 32 29,862.88 4.71 4.9
P15532 Nucleoside diphosphate kinase A 0.80 ± 0.11 0.70 ± 0.12 390 13 83 17,207.80 6.84 6.8 R.TFIAIKPDGVQR.G
K.EISLWFQPEELVEYK.S
K.YMHSGPVVAMVWEGLNVVK.T
K.YMHSGPVVAMVWEGLNVVK.T + Oxidation (M)
P18872 Guanine nucleotide- binding protein G(o) subunit alpha 1 1.18 ± 0.57 1.57 ± 1.02 90 12 28 39,953.35 5.34 5.4 R.IGAGDYQPTEQDILR.T
P29387 Guanine nucleotide- binding protein subunit beta 4 0.26 ± 0.07 0.2 ± 0.03 81 8 39 37,247.83 5.74 5.7
P31938 Dual specificity mitogen-activated protein kinase kinase 1 (1) 0.45 ± 0.07 0.38 ± 0.08 333 14 44 43,342.85 6.26 6.1 K.LPSGVFSLEFQDFVNK.C
K.LCDFGVSGQLIDSMANSFVGTR.S
K.ELELLFGCHVEGDAAETPPRPR.T
(2) 0.26 ± 0.07 0.27 ± 0.07 264 8 29 43,342.85 4.62 6.2 K.LPSGVFSLEFQDFVNK.C
K.LCDFGVSGQLIDSMANSFVGTR.S
K.ELELLFGCHVEGDAAETPPRPR.T
P42208 Septin-2 (1) 0.20 ± 0.07 0.20 ± 0.04 358 15 51 41,525.52 6.10 6.1 K.TIISYIDEQFER.Y
R.LTVVDTPGYGDAINCR.D
K.STLINSLFLTDLYPER.I
(2) 0.09 ± 0.05 0.09 ± 0.06 67 7 32 41,525.52 6.10 6.0
P53810 Phosphatidylinositol transfer protein alpha isoform 0.45 ± 0.14 0.40 ± 0.11 252 13 44 31,762.20 5.98 6.1 K.AWNAYPYCR.T
K.HVEAIYIDIADR.S
K.IETWHKPDLGTQENVHK.L
R.VILPVSVDEYQVGQLYSVAEASK.N
P53994 Ras-related protein Rab-2A 0.27 ± 0.08 0.23 ± 0.08 125 5 33 23,547.52 6.08 6.1 R.FQPVHDLTIGVEFGAR.M
P54227 Stathmin (1) 0.51 ± 0.08 0.56 ± 0.08 71 1 8 17,143.27 5.76 5.7 R.ASGQAFELILSPR.S
(2) 0.43 ± 0.06 0.44 ± 0.08 66 1 8 17,143.27 5.76 5.5 R.ASGQAFELILSPR.S
P61982 14-3-3 protein gamma (1) 0.49 ± 0.28 0.61 ± 0.34 363 12 53 28,171.40 4.80 5.2 K.TAFDEAIAELDTLNEESYK.D
(2) 0.58 ± 0.24 0.74 ± 0.21 566 16 62 4.9 K.DSTLIMQLLR.D
K.EHMQPTHPIR.L
K.NVTELNEPLSNEER.N
K.TAFDDAIAELDTLNEDSYK.D
(3) 0.50 ± 0.26 0.52 ± 0.20 412 12 53 28,171.40 4.80 5.2 K.NVTELNEPLSNEER.N
K.TAFDDAIAELDTLNEDSYK.D
(4) 0.25 ± 0.24 0.24 ± 0.10 124 8 36 28,171.40 4.80 5.2 K.ELEAVCQDVLSLLDNYLIK.N
P62137 Serine/threonine- protein phosphatase PP1-alpha catalytic subunit 0.16 ± 0.04 0.16 ± 0.04 425 17 60 37,540.09 5.94 5.9 R.YPENFFLLR.G
R.AHQVVEDGYEFFAK.R
K.ICGDIHGQYYDLLR.L
R.EIFLSQPILLELEAPLK.I
P62141 Serine/threonine- protein phosphatase PP1-beta catalytic subunit 0.19 ± 0.08 0.23 ± 0.08 256 16 59 37,055.64 5.85 5.8 K.ICGDIHGQYTDLLR.L
K.TFTDCFNCLPIAAIVDEK.I
P62259 14-3-3 protein epsilon 0.34 ± 0.19 0.53 ± 0.45 404 14 50 29,173.90 4.63 4.85 R.YLAEFATGNDR.K
K.AASDIAMTELPPTHPIR.L
K.AASDIAMTELPPTHPIR.L + Oxidation (M)
K.AAFDDAIAELDTLSEESYK.D
P62880 Guanine nucleotide- binding protein G(I)/G(S)/G(T) subunit beta 2 3.10 ± 3.33 1.02 ± 0.24 475 16 45 37,199.84 5.60 5.5 K.IYAMHWGTDSR.L
R.ELPGHTGYLSCCR.F
K.ACGDSTLTQITAGLDPVGR.I
R.KACGDSTLTQITAGLDPVGR.I
P62881 Guanine nucleotide- binding protein subunit beta 5 0.10 ± 0.05 0.10 ± 0.08 169 6 23 43,565.27 6.01 5.7 K.LHDVELHQVAER.V
K.ESIIFGASSVDFSLSGR.L
P63028 Translationally-controlled tumor protein 0.21 ± 0.06 0.23 ± 0.11 116 5 40 19,462.17 4.76 5.2 R.DLISHDELFSDIYK.I
P63085 Mitogen-activated protein kinase 1 0.85 ± 0.16 0.80 ± 0.18 306 13 52 41,144.41 6.53 7.0 K.ISPFEHQTYCQR.T
R.FRHENIIGINDIIR.A
R.VADPDHDHTGFLTEYVATR.W
P63087 Serine/threonine- protein phosphatase PP1-gamma catalytic subunit 0.15 ± 0.05 0.12 ± 0.03 212 12 45 36,983.79 6.12 6.1 R.YPENFFLLR.G
K.ICGDIHGQYYDLLR.L
P63101 14-3-3 protein zeta/delta 0.66 ± 0.26 1.12 ± 0.56 300 15 58 27,771.14 4.73 4.9 K.DSTLIMQLLR.D
K.DSTLIMQLLR.D + Oxidation (M)
K.GIVDQSQQAYQEAFEISK.K
K.TAFDEAIAELDTLSEESYK.D
P70296 Phosphatidylethanolamine-binding protein 1
(1) 1.17 ± 0.61 1.22 ± 0.58 274 13 72 20,699.25 5.19 5.2 K.LYTLVLTDPDAPSR.K
K.GNDISSGTVLSDYVGSGPPSGTGLHR.Y
(2) 1.73 ± 0.32 1.80 ± 0.23 80 7 63 20,699.25 5.19 5.4
(3) 0.80 ± 0.37 0.66 ± 0.27 298 9 65 20,699.25 5.19 4.9 K.LYTLVLTDPDAPSR.K
K.GNDISSGTVLSDYVGSGPPSGTGLHR.Y
Q01768 Nucleoside diphosphate kinase B 0.82 ± 0.28 0.91 ± 0.16 369 10 69 17,363.07 6.97 7.2 DRPFFPGLVK.Y
R.TFIAIKPDGVQR.G
R.VMLGETNPADSKPGTIR.G
K.EIHLWFKPEELIDYK.S
Q06138 Similar to Calcium- binding protein 39, Q06138 (100%) 0.10 ± 0.08 0.10 ± 0.03 138 13 39 39,841.97 6.69 7.0 K.DVAQIFNNILR.R
R.NIQFEAFHVFK.V
K.LLSAEFLEQHYDR.F
Q08331 Calretinin 0.50 ± 0.17 0.44 ± 0.18 172 10 42 31,372.64 4.94 5.2 R.LLPVQENFLLK.F
K.ELENFFQELEK.A
Q3TBA0 Similar to SEPTIN6 type II homolog 0.40 ± 0.10 0.40 ± 0.09 110 10 36 48,951.79 6.36 6.4 K.FESDPATHNEPGVR.L
Q3TBI9 Guanosine diphosphate (GDP) dissociation inhibitor 1, full insert sequence 0.42 ± 0.31 0.42 ± 0.12 554 31 66 50,539.61 4.95 5.2 K.FLVFVANFDENDPK.T
K.SPYLYPLYGLGELPQGFAR.L
K.FDLGQDVIDFTGHALALYR.T
K.NTNDANSCQIIIPQNQVNR.K
Q3THY7 Guanine nucleotide- binding protein, beta 2, related sequence 1, full insert sequence 0.41 ± 0.14 0.39 ± 0.16 158 12 64 35,048.67 7.06 7.5 K.HLYTLDGGDIINALCFSPNR.Y
Q3U1B1 Guanine nucleotide- binding protein, beta 1, full insert sequence 1.82 ± 1.03 1.95 ± 0.97 271 12 54 37,404.04 5.75 5.5 R.ELAGHTGYLSCCR.F
K.ACADATLSQITNNIDPVGR.I
Q3U5X4 Annexin A5, full insert sequence 0.23 ± 0.11 0.19 ± 0.09 137 11 37 35,752.44 4.83 5.2 K.GLGTDEDSILNLLTSR.S
Q3UKW2 Calmodulin 1, full insert sequence 3.71 ± 0.60 3.95 ± 1.01 133 5 27 21,559.82 4.21 4.1 R.VFDKDGNGYISAAELR.H
Q3UL78 Cell division cycle 42 homolog (Saccharomyces cerevisiae), full insert sequence (1) 0.33 ± 0.07 0.35 ± 0.09 165 5 61 16,503.07 6.14 5.8 K.TPFLLVGTQIDLR.D
(2) 0.21 ± 0.04 0.18 ± 0.05 163 5 61 16,503.07 6.14 6.4 K.TPFLLVGTQIDLR.D
Q3UM45 Protein phosphatase 1 regulatory subunit 7 0.13 ± 0.05 0.16 ± 0.09 154 14 49 41,291.95 4.85 5.15 K.LQNLDALTNLTVLSVQSNR.L
Q3UUX9 Guanosine diphosphate (GDP) dissociation inhibitor 3, full insert sequence (1) 0.14 ± 0.06 0.17 ± 0.05 81 10 33 50,537.13 5.93 5.95
(2) 0.24 ± 0.11 0.21 ± 0.10 315 25 62 50,537.13 5.93 5.9 K.SPYLYPLYGLGELPQGFAR.L
K.FDLGQDVIDFTGHSLALYR.T
Q3UWP8 Calreticulin, full insert sequence. [Fragment] 0.45 ± 0.15 0.54 ± 0.19 84 10 41 42,195.92 4.57 4.7
Q3V067 Protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I), full insert sequence (1) 0.63 ± 0.11 0.75 ± 0.24 484 10 65 18,207.72 4.73 4.9 K.DGYISNGELFQVLK.M
R.VIDIFDTDGNGEVDFK.E
R.ISFEEFCAVVGGLDIHK.K
(2) 0.70 ± 0.13 0.69 ± 0.14 431 9 65 18,207.72 4.73 4.9 K.DGYISNGELFQVLK.M
R.VIDIFDTDGNGEVDFK.E
R.ISFEEFCAVVGGLDIHK.K
Q543N6 Protein phosphatase 2a, regulatory subunit B′ (PP2A, subunit B′, PR53 isoform) 0.10 ± 0.04 0.10 ± 0.04 74 7 32 36,710.15 5.95 6.0
Q545R3 N-myc downstream regulated 1, full insert sequence 0.11 ± 0.02 0.10 ± 0.02 67 10 29 43,008.65 5.96 5.78
Q60631 Growth factor receptor-bound protein 2 (1) 0.46 ± 0.01 0.05 ± 0.01 165 5 61 16,503.07 6.14 5.8 K.TPFLLVGTQIDLR.D
(2) 0.18 ± 0.03 0.17 ± 0.03 163 5 61 16,503.07 6.14 5.8 K.TPFLLVGTQIDLR.D
Q60829 Dopamine- and cAMP- regulated neuronal phosphoprotein 0.41 ± 0.30 0.38 ± 0.13 71 5 45 21,780.53 4.60 5.0
Q60932 Voltage-dependent anion-selective channel protein 1 (1) 1.03 ± 0.33 1.16 ± 0.41 743 5 72 32,351.49 8.55 8.4 K.KLETAVNLAWTAGNSNTR.F
K.VNNSSLIGLGYTQTLKPGIK.L
R.EHINLGCDVDFDIAGPSIR.G
K.WNTDNTLGTEITVEDQLAR.G
K.TDEFQLHTNVNDGTEFGGSIYQK.V
(2) 1.00 ± 0.44 0.94 ± 0.46 532 13 59 32,351.49 8.55 8.5 R.WTEYGLTFTEK.W
R.EHINLGCDVDFDIAGPSIR.G
K.WNTDNTLGTEITVEDQLAR.G
K.TDEFQLHTNVNDGTEFGGSIYQK.V
(3) 1.12 ± 0.45 1.10 ± 0.34 442 13 60 32,351.49 8.55 7.5 K.YQVDPDACFSAK.V
K.WNTDNTLGTEITVEDQLAR.G
K.TDEFQLHTNVNDGTEFGGSIYQK.V
(4) 0.46 ± 0.12 0.43 ± 0.14 100 8 49 32,351.49 8.55 6.8
(5) 0.95 ± 0.29 0.97 ± 0.20 360 12 55 32,351.49 8.55 6.9 R.EHINLGCDVDFDIAGPSIR.G
K.WNTDNTLGTEITVEDQLAR.G
(6) 0.32 ± 0.07 0.28 ± 0.08 321 10 48 32,351.49 8.55 6.5 R.WTEYGLTFTEK.W
R.EHINLGCDVDFDIAGPSIR.G
K.WNTDNTLGTEITVEDQLAR.G
K.TDEFQLHTNVNDGTEFGGSIYQK.V
Q62048 Astrocytic phosphoprotein PEA-15 0.30 ± 0.11 0.28 ± 0.11 109 5 36 15,054.13 4.94 5.2 K.DNLSYIEHIFEISR.R
Q63844 Mitogen-activated protein kinase 3 0.06 ± 0.04 0.08 ± 0.05 75 8 34 42,935.30 6.16 6.2
Q6P1F6 Similar to Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B, alpha isoform, Q6P1F6 (95%) 0.25 ± 0.08 0.24 ± 0.07 147 16 41 51,692.08 5.82 6.0 R.INLWHLEITDR.S
Q6PI18 Similar to Valosin containing protein, Q6PI18 (91%) 0.22 ± 0.12 0.24 ± 0.22 138 17 30 89,321.80 5.14 5.65
Q76MZ3 Serine/threonine- protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 0.47 ± 0.23 0.42 ± 0.16 150 20 38 65,191.42 5.00 5.2
Q78MH6 Voltage-dependent anion channel 2 (1) 0.87 ± 0.27 0.72 ± 0.16 101 6 37 31,732.84 7.44 7.2 K.VNNSSLIGVGYTQTLRPGVK.L
(2) 0.43 ± 0.09 0.40 ± 0.09 417 10 53 6.1 K.WCEYGLTFTEK.W
K.VNNSSLIGVGYTQTLRPGVK.L
K.VCEDFDTSVNLAWTSGTNCTR.F
R.TGDFQLHTNVNNGTEFGGSIYQK.V
Q8BG73 SH3 domain-binding glutamic acid-rich-like protein 2 0.17 ± 0.10 0.15 ± 0.09 233 4 53 12,254.96 5.49 5.7 R.YCGDYDSFFESK.E
K.KPAQGNPLPPQIFNGDR.Y
Q8BN07 Protein phosphatase 2a, catalytic subunit, beta isoform, full insert sequence. [Fragment] 0.13 ± 0.10 0.26 ± 0.25 126 12 50 32643.82 5.37 5.4 K.YSFLQFDPAPR.R
Q8BNF8 Valosin containing protein, full insert sequence 0.09 ± 0.08 0.13 ± 0.18 135 15 34 80,149.37 5.12 5.4
Q8BPI0 RHOGDI-1 homolog [Fragment] (1) 0.29 ± 0.07 0.60 ± 0.01 245 12 56 22,947.89 5.20 5.4 R.VAVSADPNVPNVIVTR.L
R.AEEYEFLTPMEEAPK.G
R.AEEYEFLTPMEEAPK.G + Oxidation (M)
R.LTLVCSTAPGPLELDLTGDLESFK.K
(2) 0.42 ± 0.12 0.46 ± 0.20 192 9 46 22,947.89 5.20 5.3 R.VAVSADPNVPNVIVTR.L
K.SIQEIQELDKDDESLR.K
(3) 0.11 ± 0.08 0.13 ± 0.09 164 11 52 22,947.89 5.20 5.2 R.VAVSADPNVPNVIVTR.L
Q8BXS6 SH3 domain protein 2A, full insert sequence 0.23 ± 0.06 0.29 ± 0.10 152 8 35 39,941.27 5.20 5.5 K.QAVQILQQVTVR.L
R.ALYDFEPENEGELGFK.E
Q8C1B7 Septin-11 (1) 0.17 ± 0.06 0.15 ± 0.04 411 18 47 49,563.45 6.26 6.8 R.SLFNYHDTR.I
K.FESDPATHNEPGVR.L
R.NLSLSGHVGFDSLPDQLVNK.S
(2) 0.27 ± 0.05 0.25 ± 0.05 159 12 44 49,563.45 6.26 6.4 K.FESDPATHNEPGVR.L
Q8C2L2 2 days neonate thymus thymic cells cDNA, RIKEN full-length enriched library, clone:E430014P14 product:septin 6, full insert sequence. 0.134 ± 0.03 0.12 ± 0.04 94 9 48 39,698.18 5.56 6.2 R.TVPLAGHVGFDSLPDQLVNK.S
Q8CEG4 Similar to valosin containing protein, full insert sequence, Q8CEG4 (97%) 0.28 ± 0.10 0.27 ± 0.09 143 7 19 89,363.88 5.14 5.65 R.EDEEESLNEVGYDDIGGCR.K
Q8CHH9 Septin-8 (1) 0.16 ± 0.04 0.19 ± 0.06 91 13 41 49,681.19 5.68 5.8
(2) 0.13 ± 0.05 0.12 ± 0.03 71 9 32 49,681.19 5.86 5.8
(3) 0.12 ± 0.04 0.13 ± 0.03 99 10 40 49,681.19 5.68 5.7
Q8JZR2 Crk protein 0.36 ± 0.11 0.38 ± 0.12 70 6 51 22,889.53 5.33 5.4
Q99K69 RAS protein activator like 1 0.04 ± 0.03 0.04 ± 0.03 104 12 25 89,394.80 5.95 6.1
Q9CQI6 Coactosin-like protein 0.23 ± 0.05 0.25 ± 0.05 104 3 39 15,812.72 5.28 5.2 R.DDGSAVIWVTFR.Y dimethylaminohydrolase 1
Q9CWS0 NG,NG- dimethylarginine 0.43 ± 0.13 0.45 ± 0.11 399 14 46 31,249.78 5.64 5.7 K.VDGLLTCCSVFINK.K
K.DENATLDGGDVLFTGR.E
K.DYAVSTVPVADSLHLK.S
K.LTVPDDMAANCIYLNIPSK.G
Q9D7X3 Dual specificity protein phosphatase 3 0.15 ± 0.063 0.12 ± 0.06 114 7 45 20,472.15 6.07 7.5 K.ANDTQEFNLSAYFER.A
R.EIGPNDGFLAQLCQLNDR.L
Q9DC07 LIM and SH3 protein (LASP Homolog), full insert sequence 0.70 ± 0.19 0.62 ± 0.20 91 10 43 31,113.09 8.54 8.1 R.AMYDYSAQDEDEVSFR.D + Oxidation (M)
Q9R1T4 Septin-6 0.18 ± 0.03 0.19 ± 0.04 107 9 42 49,488.37 6.04 6.2
Q9Z2Q6 Septin-5 (1) 0.56 ± 0.18 0.41± 0.07 450 17 50 42,747.94 6.21 6.2 K.DVTCDVHYENYR.A
K.QYVGFATLPNQVHR.K
K.ESAPFAVIGSNTVVEAK.G
R.LYPWGIVEVENQAHCDFVK.L
(2) 0.19 ± 0.05 0.18 ± 0.05 65 5 21 42,747.94 6.21 6.1
(3) 0.09 ± 0.04 0.10 ± 0.04 68 7 32 41,525.52 6.10 6.0
(4) 0.18 ± 0.06 0.19 ± 0.06 65 7 33 42,747.94 6.21 6.2