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. 2010 May 5;35(9):1897–1909. doi: 10.1038/npp.2010.61

Figure 4.

Figure 4

Greater NAS inhibition in neurons from 1- and 2-day FZP-withdrawn rats. Representative AMPAR-mediated mEPSCs (a, 1 day; d, 2 days) recorded before (solid line) and after (dotted line) external application of the potent spermine analog, NAS (100 μM). The percent NAS inhibition of mEPSC current amplitude was increased (b, 1 day; e, 2 days) in CA1 neurons from FZP-withdrawn rats (p<0.05). Bath application of NAS abolished the increased AMPAR-mediated mEPSC amplitude in FZP-withdrawn neurons after (c) 1 day (n=7) and (f) 2 days (n=12) and was without effect in control neurons (1 day, n=6; 2 days, n=7), supporting the hypothesis that AMPAR current potentiation is mediated by synaptic incorporation of GluA2-lacking AMPARs. Asterisks denote p⩽0.05 or **p⩽0.01.