Table 2.
TPE intervals by genotype and effect of SNPs on electrocardiographic TPE interval
| Allele* and amino acid changes |
Major homozygotes |
Heterozygotes |
Minor homozygotes |
Minor allele effect§ |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Gene | SNP | TPE† (ms) | % | TPE† (ms) | % | TPE† (ms) | % | ΔTPE† (ms) | P | |
| KCNH2 | rs1805123 | A→C, K897T | 83.8 | 67.9 | 82.5 | 28.8 | 81.6 | 3.3 | −1.2 | .00005 |
| rs3807375 | G→A | 82.7 | 32.4 | 83.7 | 49.4 | 84.1 | 18.2 | +0.8 | .001 | |
| KCNE1 | rs1805128 | G→A, D85N | 83.4 | 97.3 | 81.7 | 2.6 | 83.9 | 0.1 | −1.3 | .20 |
| NOS1AP | rs2880058 | A→G | 83.7 | 42.3 | 83.4 | 45.5 | 82.1 | 12.2 | −0.6 | .01 |
| rs4657139 | T→A | 83.6 | 41.3 | 83.5 | 46.1 | 82.1 | 12.6 | −0.5 | .03 | |
| rs10918594 | C→G | 83.9 | 43.8 | 83.3 | 44.0 | 82.0 | 12.3 | −0.8 | .002 | |
| rs10494366 | T→G | 83.7 | 41.6 | 83.4 | 45.7 | 82.3 | 12.7 | −0.6 | .02 | |
Values are mean.
*
Major→minor allele.
†
Maximum precordial TPE interval. Percentages refer to prevalence estimates.
§
Additive genetic model with the values representing differences from major homozygotes per one minor allele (adjustment for gender, age, systolic blood pressure, coronary heart disease, previous myocardial infarction, Cornell voltage-duration product). SNP=single nucleotide polymorphism, TPE=T-wave peak to T-wave end interval.