Table 2.
Allele* and amino acid changes |
Major homozygotes |
Heterozygotes |
Minor homozygotes |
Minor allele effect§ |
||||||
---|---|---|---|---|---|---|---|---|---|---|
Gene | SNP | TPE† (ms) | % | TPE† (ms) | % | TPE† (ms) | % | ΔTPE† (ms) | P | |
KCNH2 | rs1805123 | A→C, K897T | 83.8 | 67.9 | 82.5 | 28.8 | 81.6 | 3.3 | −1.2 | .00005 |
rs3807375 | G→A | 82.7 | 32.4 | 83.7 | 49.4 | 84.1 | 18.2 | +0.8 | .001 | |
KCNE1 | rs1805128 | G→A, D85N | 83.4 | 97.3 | 81.7 | 2.6 | 83.9 | 0.1 | −1.3 | .20 |
NOS1AP | rs2880058 | A→G | 83.7 | 42.3 | 83.4 | 45.5 | 82.1 | 12.2 | −0.6 | .01 |
rs4657139 | T→A | 83.6 | 41.3 | 83.5 | 46.1 | 82.1 | 12.6 | −0.5 | .03 | |
rs10918594 | C→G | 83.9 | 43.8 | 83.3 | 44.0 | 82.0 | 12.3 | −0.8 | .002 | |
rs10494366 | T→G | 83.7 | 41.6 | 83.4 | 45.7 | 82.3 | 12.7 | −0.6 | .02 |
Values are mean.
Major→minor allele.
Maximum precordial TPE interval. Percentages refer to prevalence estimates.
Additive genetic model with the values representing differences from major homozygotes per one minor allele (adjustment for gender, age, systolic blood pressure, coronary heart disease, previous myocardial infarction, Cornell voltage-duration product). SNP=single nucleotide polymorphism, TPE=T-wave peak to T-wave end interval.