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. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: Bone Marrow Transplant. 2010 Apr 12;46(1):20–26. doi: 10.1038/bmt.2010.53

Table 2. F-ara-A pharmacokinetic parameters with first dose of fludarabine1.

Standard Dose Dose-Reduced
N 78 9
Fludarabine dose 40mg/m2 30-35mg/m2
Creatinine Clearance, mL/min 85.9(49.5-153.2) 57.1(50.5-65.1)
Cmax, ng/mL 958 (384-2046) 798 (694-1073)
Cmin trough, ng/mL 52 (17-166) 69 (39-93)
AUC(0-∞), ug*hr/mL 4.9 (2.0-11.5) 5.5 (4.3-7.0)
Volume of distribution, L/kg 1.95 (0.89-4.78) 1.72 (1.40-2.51)
Clearance, L/hr 16.0 (6.2-36.6) 11.5 (6.9-15.2)
Half-life, hours 8.53 (3.75-22.18) 10.32 (7.81-14.48)
Dayzero2, ng/mL 15.0 (0.1-144.1) 19.0 (4.0-63.6)
1

data are median (range),

2

single concentration obtained on day of transplant