Table 3. Multiple regression analysis of TRM at 6 months following nonmyeloablative HCT.
Factor | Relative Risk of TRM (95% CI) | P-value |
---|---|---|
F-ara-A AUC(0-∞) | .02 | |
≤ 6.5 ug hr/mL* | 1.00 | |
> 6.5 ug hr/mL | 4.56 (1.22-17.14) | |
Age (yrs) | .89 | |
< 55* | 1.00 | |
≥ 55 | 0.92 (0.26-3.20) | |
ATG in conditioning regimen | .09 | |
Yes* | 1.00 | |
No | 0.36 (0.11-1.19) | |
Recipient CMV status | .93 | |
Negative* | 1.00 | |
Positive | 0.94 (0.27-3.34) | |
Donor Source | .97 | |
Matched-related* | 1.00 | |
Unrelated | 1.03 (0.31-3.40) | |
Comorbidity Score | .18 | |
0* | 1.00 | |
1-2 | 0.22 (0.04-1.25) | |
≥3 | 0.60 (0.12-2.98) | |
Creatinine clearance | .41 | |
≥ 70 ml/min* | 1.00 | |
< 70 ml/min | 1.63 (0.52-5.13) | |
aGVHD grades III-IV | .15 | |
No* | 1.00 | |
Yes | 2.91 (0.67-12.60) |
reference group