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. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: Heart Rhythm. 2010 Mar 27;7(7):973–980. doi: 10.1016/j.hrthm.2010.03.038

Figure 6. HERGN598Q with reduced membrane residence time, not rescued by KCNQ1.

Figure 6

(A) Tail current density measured at -50 mV after a test pulse to + 20 mV of WT HERG (n = 17) and HERGN598Q (n=19). (B), Normalized I-V relationships for tail currents of WT HERG (n = 12) and HERGN598Q (n=9). (C), Normalized steady-state inactivation curves of WT HERG (n = 8) and HERGN598Q (n=9). (D), Deactivation time constants of WT HERG (open and closed circles, n=11) and HERGN598Q (n=9). (E), Representative traces from CHO cells expressing HERGN598Q, and HERGN598Q+KCNQ1. Inset, voltage protocol. Current-voltage relationship of tail currents of HERGN598Q (n=15) and HERGN598Q + KCNQ1 (n=15). Dofetilide sensitive currents only are represented.