Figure 6.

Comparison of hazard ratios (HRs) for coronary heart disease by long-term average concentrations of fasting blood glucose concentration, total (and non-HDL) cholesterol, and systolic blood pressure, in a common set of participants

Analyses were done in participants with no known history of diabetes at baseline. Analyses of fasting blood glucose concentration, total cholesterol, and systolic blood pressure were based on 140 624 participants (10 667 cases). For fasting blood glucose, participants were classified into groups of baseline fasting concentrations, as described in figure 4. For the other factors presented, participants were classified according to baseline values as follows: total cholesterol, <4·5, 4·5–5·1, 5·1–5·7, 5·7–6·3, 6·3–6·9, 6·9–7·5, 7·5–8·1, 8·1–8·7, ≥8·7 mmol/L; non-HDL cholesterol, <3, 3–3·6, 3·6–4·2, 4·2–4·8, 4·8–5·4, 5·4–6·0, 6·0–6·6, 6·6–7·2, ≥7·2 mmol/L; systolic blood pressure: <110, 110–120, 120–130, 130–140, 140–150, 150–160, 160–170, 170–180, ≥180 mm Hg). These categories approximately correspond to those used for fasting blood glucose concentration (ie, increments of half the SD of each factor). HRs were adjusted, where appropriate, for age, smoking status, BMI, systolic blood pressure, total cholesterol and fasting blood glucose, and stratified, where appropriate, by sex and trial arm. HRs were plotted against the mean value in each group. Long-term average values were calculated with information from serial measurements. The reference group for each factor is the category with the lowest HR. *Analyses of non-HDL cholesterol were based on a subset of 71 224 participants (4290 cases).