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. Author manuscript; available in PMC: 2010 Jul 16.
Published in final edited form as: Reprod Domest Anim. 2008 Jul;43(Suppl 2):386–392. doi: 10.1111/j.1439-0531.2008.01189.x

Fig. 4.

Fig. 4

Influence of GDNF and Jagged-1 on SSCs in vitro. (a) Example of a colony of SSCs grown in vitro (from Braydich-Stolle et al. 2007). (b) Example of a chain of differentiating spermatogonia grown in vitro (from Hofmann et al. 2006). (c) Number of colonies and chains of spermatogonia obtained after culturing SSCs with 100 ng/ml GDNF for 3 and 6 days. (d) Number of colonies and chains of spermatogonia obtained after culturing SSCs with 10 µg/ml Jagged-1 for 3 and 6 days. A significant increase in the number of chains can be observed, indicating that Jagged-1 mediates SSC differentiation (*p < 0.05, Student’s t-test)