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. Author manuscript; available in PMC: 2011 Jul 30.
Published in final edited form as: Brain Res. 2010 May 27;1346:174–182. doi: 10.1016/j.brainres.2010.05.063

Figure 1. Short-term atipamezole enhances rehabilitation-aided motor improvement in skilled forelimb reaching after permanent MCAO.

Figure 1

Time course of motor performance- All animals enrolled in the study achieved the preoperative criteria of an average of 16 successes in 20 attempts for 3 days prior to surgery. At Day 2 Post-op, prior to any treatment, the mean deficit in reaching was not significantly different among groups (F3,36 = 0.14, p = 0.93). A one-way ANOVA on Ranks established an overall treatment effect (H = 20.6 with 3 degrees of freedom, p<0.001) and Dunn’s post-hoc test established that ATI/REHAB produced a significant overall enhancement in reaching performance compared to either vehicle-treated group (*, p<0.05). Data represent the mean ± SEM for following number of animals/group: VEH/CON = 9, VEH/REHAB = 9, ATI/CON = 9, ATI/REHAB = 10.