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. Author manuscript; available in PMC: 2011 Jul 30.
Published in final edited form as: Brain Res. 2010 May 27;1346:174–182. doi: 10.1016/j.brainres.2010.05.063

Figure 3. Short-term atipamezole enhances motor improvement in ladder rung walking after permanent MCAO regardless of physical rehabilitation.

Figure 3

Time course of motor performance- At Day 2 Post-op, prior to any treatment, the mean deficit in skilled forelimb placement was not significantly different among groups (F3,36 = 2.47, p = 0.08). A one-way ANOVA on Ranks established an overall treatment effect (H = 63.3 with 3 degrees of freedom, p<0.001) and Dunn’s post-hoc test established that ATI/REHAB produced a significant overall enhancement in ladder rung walking performance compared to all other treatment groups (*, p<0.05). Post-hoc analysis also revealed a significant overall enhancement in performance in ATI/CON compared to either vehicle-treated group (+, p<0.05). Data represent the mean ± SEM for following number of animals/group: VEH/CON = 9, VEH/REHAB = 9, ATI/CON = 9, ATI/REHAB = 10.