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. Author manuscript; available in PMC: 2011 Jun 30.
Published in final edited form as: Respir Physiol Neurobiol. 2010 Apr 23;172(1-2):42–52. doi: 10.1016/j.resp.2010.04.008

Fig. 2.

Fig. 2

5-HT3 agonists modulate respiratory burst discharge. mCPBG (50 μM) and PBG (20 μM) increased burst frequency during drug application with the PBG-dependent increase persisting during washout (A, B). mCPBG and PBG reduced bursts/episode during drug application (C). While bursts/episode returned close to baseline during washout in PBG treated brainstems, the decrease persisted 2 h after mCPBG application (D). Control studies show a slow increase in the number of brainstems producing singlet discharge (<1.25 bursts/episode), and a corresponding decrease in brainstems producing episodic discharge (>1.75 bursts/episode) (E). mCPBG and PBG transformed episodic discharge to singlet discharge (F, G). Symbols: *P<0.05 compared to controls at that time point; †P<0.05 for drug effect; values which differ significantly (P<0.05) from the baseline value are indicated by a solid symbol.