. Author manuscript; available in PMC: 2011 Jun 15.

Published in final edited form as: Bioorg Med Chem. 2010 Apr 29;18(12):4363–4373. doi: 10.1016/j.bmc.2010.04.089

Table 2.

Anti-HIV data of seco-DCK analogs (7–10) in MT-4 cell line^a

Compd	IC₅₀ (μM)	HIV-1_NL4-3		RTMDR

		EC₅₀ (μM)	TI	EC₅₀ (μM)	TI
6	20	20	NS	20	NS
7	20	20	NS	20	NS
8	20	20	NS	20	NS
9	17.27	0.5	34.8	1.89	9.13
3	9.27	0.08	116	0.133	69.9

All data presented are averages of at least three separate experiments performed by Dr. Chin-Ho Chen, Duke University, NC.

CC₅₀: concentration that inhibits uninfected MT-4 cell growth by 50%. EC₅₀: concentration that inhibits viral replication by 50%. TI = therapeutic index IC₅₀/EC₅₀. NS: no suppression at the highest tested concentration (20 μM).