. Author manuscript; available in PMC: 2011 Jun 15.

Published in final edited form as: Bioorg Med Chem. 2010 Apr 29;18(12):4363–4373. doi: 10.1016/j.bmc.2010.04.089

Table 3.

Anti-HIV-1_NL4-3 data of seco-DCK analogs (10–16) in MT-4 cell line^a

Compd	IC₅₀ (μM)	EC₅₀ (μM)	TI
10	62.4	36.61	1.71
11	60.3	32.3	1.87
12	54.5	44.65	1.22
13	56.24	4.67	12.04
14	25	25	1
15	56.62	5.66	8
16	34.72	4.69	15
9	44.7	1.98	22.53

All data presented are averages of at least three separate experiments performed by Dr. Chin-Ho Chen, Duke University, NC.

CC₅₀: concentration that inhibits uninfected MT-4 cell growth by 50%. EC₅₀: concentration that inhibits viral replication by 50%. TI = therapeutic index IC₅₀/EC₅₀. NS: no suppression at the highest tested concentration (20 μM).