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Structure of TLS–CHOP and EWS–FLI1 fusion proteins. TLS and EWS are as described in Figure 1. CHOP contains a DNA-binding domain (DBD) and a Leucine Zipper (LZ) domain. Translocation breakpoint occurs upstream of the CHOP initiation site; TLS–CHOP fusion protein contains amino acids derived from sequences in the 5′ UTR of CHOP (hatched region). FLI1 contains an activation domain (AD) and an ETS DBD.
