Figure 4.

(a) Shape deformations for the cases $\tilde{\Lambda }=0.75$ and $\tilde{b}=0.1$ at scaled times $\tilde{t}$ = 3000, 4000, 4100, 4150, 4300, 4500, and 5500 from the initial spherical vesicle ($\tilde{t}$ =0) with a single pore. In the shape at $\tilde{t}$ =5500, the region with δϕ_DHPC (S_o,t) > 0 is drawn by the solid line and the one with δϕ_DHPC (S_o,t) < 0 is drawn by the dotted line. (b) The area fraction difference in DHPC between inner and outer leaflets $\delta {\varphi }_{\text{DHPC}}(S_{\text{o}},t)$ at $\tilde{t}$ = 4000, 4100, 4300, and 5500 as functions of $S_{\text{o}}$ defined as the contour length measured from the intersection point of the vesicle with the z axis at $\tilde{t}$ = 0. (c) The axisymmetric three-dimensional figure of the initial shape ($\tilde{t}$ = 0) and the vesicle with a rolled rim at $\tilde{t}$ = 5500 in panel a.