Figure 1.
Three-step strategy for constructing Aβ25-35 micelles with parallel and antiparallel peptide orientations. Step 1: A single peptide is aligned to the z axis. Step 2: The peptide is replicated and rotated along the y axis at every 30° to form a semicircle by peptides A–G. The relative orientation (parallel versus antiparallel) and displacement between adjacent peptides are adjusted within the semicircle. Step 3: Peptides B–F (but not A and G) are rotated and copied along the z axis at every 30° to form a micelle consisting of 62 peptides.