Table 1.
Representative preclinical animal studies using adipose-derived stromal/stem cells and stromal vascular fraction cells
| Tissue type | Defect | Species | References |
|---|---|---|---|
| Adipose/soft tissue | Fat pad generation | Murine, rat, ovine | [51-60] |
| Lipodystrophy | Murine | [48,61] | |
| Burn/radiation trauma | Murine | [62-64] | |
| Bone | Critical sized defect | ||
| Craniofacial | Murine, rat | [65,66] | |
| Long bone | Murine | [67] | |
| Spinal fusion | Rat | [68,69] | |
| Cardiac | Myocardial infarction | Murine, rat | [42,43,70,71] |
| Central nervous system | Vascular injury/stroke | Murine, rat | [44,46,72] |
| Spinal cord trauma | Rat | [47] | |
| Multiple sclerosis | Murine | [33] | |
| Gastrointestinal tract | Crohn's disease/inflammatory bowel syndrome | Murine | [73] |
| Hematopoiesis | Bone marrow transplantation | Murine | [74,75] |
| Joint | Osteoarthritis | Canine, caprine, equine | [76-79] |
| Liver | Acute toxicity/regeneration | Murine | [80-88] |
| Pancreas | Type 1 diabetes mellitus | Murine, rat | [48,89,90] |
| Renal | Acute ischemia | Rat | (JMG, unpublished) |
| Skin | Wounds, burns | Murine, porcine | [62,64,91] |
| Tendon | Tendonitis | Equine | [92] |
| Urinary bladder | Incontinence | Rat | [93] |
| Vascular | Hind limb ischemia | Murine, rat | [36,41,45] |